Checked against the current FDA label, named clinical trials, and the sources listed on this site.
01The daily ED start is 2.5 mg
Once-daily Cialis for ED starts at 2.5 mg taken at approximately the same time every day, without regard to timing of sexual activity. The daily dose may be increased to 5 mg based on individual efficacy and tolerability.
Plasma tadalafil accumulates about 1.6-fold with once-daily dosing. Steady state is reached by day 5.
02BPH is 5 mg once daily
The recommended dose of Cialis for once daily use for BPH is 5 mg, taken at approximately the same time every day. When Cialis is used for ED and BPH, the dose is 5 mg once daily.
The combination of Cialis and alpha-blockers for BPH is not recommended. Efficacy of the combination has not been adequately studied, and both drugs can lower blood pressure. In a man already stable on an alpha-blocker who is treated for ED, Cialis should be started at the lowest recommended as-needed dose.
03Daily use when creatinine clearance is low
Once-daily Cialis for patients with creatinine clearance 30 to 50 milliliters per minute starts at 2.5 mg taken at approximately the same time every day, without regard to timing of sexual activity. The daily dose may be increased to 5 mg based on individual efficacy and tolerability. Plasma tadalafil accumulates about 1.6-fold with once-daily dosing. Steady state is reached by day 5.
Sources and how this letter was sealed
FDA / Lilly, Cialis US PI: daily ED 2.5 mg start, 5 mg; BPH 5 mg daily; accumulation ~1.6-fold; steady state by 5 days.
Method in brief: open primary sources, annotate against the current FDA label,
countersign by Dr. Nora Lindqvist, MD, then seal with a dated review.
Full walk-through on the method page and
editorial standards.
How to cite this page - Vancouver style
Juvia Pharma Drug Reference. Once-daily Cialis is 2.5 mg or 5 mg [Internet]. Stockholm: Juvia Pharma; 21 October 2026 [cited 2026 Aug 21]. Available from: https://juviapharma.com/postscripts/tadalafil-daily-background/
Desk thread
Answers follow the U.S. Cialis prescribing information.
Liv Andresen, Drammen writes
I take 5 mg every morning. Can I add 20 mg on Friday?
Desk reply
Once-daily Cialis for ED starts at 2.5 mg taken at approximately the same time every day, without regard to timing of sexual activity. The daily dose may be increased to 5 mg based on individual efficacy and tolerability. Plasma tadalafil accumulates about 1.6-fold with once-daily dosing. Steady state is reached by day 5.
Per-Olof Nygren, Lulea writes
When does a 2.5 mg daily tablet reach a steady level?
Desk reply
Once-daily Cialis for ED starts at 2.5 mg taken at approximately the same time every day, without regard to timing of sexual activity. The daily dose may be increased to 5 mg based on individual efficacy and tolerability. Plasma tadalafil accumulates about 1.6-fold with once-daily dosing. Steady state is reached by day 5.
Kaisa Lehtinen, Tampere writes
Is 5 mg daily the BPH dose or the ED daily step?
Desk reply
The recommended dose of Cialis for once daily use for BPH is 5 mg, taken at approximately the same time every day. When Cialis is used for ED and BPH, the dose is 5 mg once daily. The combination of Cialis and alpha-blockers for BPH is not recommended. Efficacy of the combination has not been adequately studied, and both drugs can lower blood pressure. In a man already stable on an alpha-blocker who is treated for ED, Cialis should be started at the lowest recommended as-needed dose.
Before you start, stop, or change any medicine mentioned above, run it past your prescriber or pharmacist - they hold your chart, this despatch does not. Desk notice.
