Juvia Pharma Drug reference

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Fifty milligrams about an hour before activity

6 min readReviewed 31 October 2026. Updated
Blue sildenafil tablet beside an empty-plate timing sketch on white

Key facts

Labelled strength50 mg start
Brand / genericViagra / sildenafil
Window to dose30 minutes to 4 hours before activity
Half-lifeAbout 4 hours (parent and N-desmethyl)
High-fat mealTmax +60 min; Cmax -29%
Absolute bioavailabilityMean 41% (range 25-63%)
Ritonavir cap25 mg once in 48 hours
Tablets25 mg, 50 mg, 100 mg

Checked against the current FDA label, named clinical trials, and the sources listed on this site.

0150 mg as needed, 30 minutes to 4 hours before activity

As-needed Viagra for ED starts at 50 mg taken about one hour before sexual activity. Viagra may be taken from 30 minutes to 4 hours before sexual activity. The as-needed dose may be 100 mg based on individual efficacy and tolerability. A 25 mg as-needed tablet may be used when a lower dose is needed. In most patients the maximum dosing frequency is once per day.

02A high-fat meal delays the peak by an hour

A high-fat meal delayed the mean Tmax of sildenafil by 60 minutes. Mean Cmax was reduced 29 percent after that meal. Viagra may be taken with or without food. In the fasted state, maximum plasma concentrations arrive between 30 and 120 minutes. The median Tmax in the fasted state is 60 minutes.

03When a nitrate can be given after Viagra

The safe time interval between Viagra and organic nitrate administration is unknown. Plasma levels of sildenafil at 24 hours post dose are about 2 ng/mL compared to approximately 440 ng/mL at peak after 100 mg in healthy volunteers. In the event of an angina attack after Viagra, nitrates should still not be administered. If nitrates are deemed medically necessary in a life-threatening situation, at least 24 hours should have elapsed.

04An erection lasting more than 4 hours

An erection lasting more than 4 hours requires emergency care, whether or not it is painful. Priapism lasting longer than 6 hours can result in penile tissue damage and permanent loss of potency. Use Viagra with caution in men with conditions that may predispose them to priapism: sickle cell anemia, multiple myeloma, leukemia, or penile deformity such as angulation, cavernosal fibrosis, or Peyronie disease.

Costco

50 mg x 4

Ask for four tablets, not the ten-count listing

Publix

50 mg x 4

Publix pharmacy landing page only

Target

50 mg x 4

Target pharmacy counter, operated by CVS

Generic sildenafil 50 mg, four tablets - a typical first prescription at the starting dose, October 2026. GoodRx listed 50 mg x 10 at $646.10 average retail and $11.35 with a coupon. Four tablets is not a published quantity, so ask the pharmacy to price four rather than assuming a share of the ten-count figure. This site does not dispense.

05Myocardial infarction in the prior 6 months

Viagra was not administered to men with myocardial infarction, stroke, or a life-threatening arrhythmia within the last 6 months in clinical trials. Until further information is available, Viagra is not recommended in that group. The same not-recommended list includes resting blood pressure less than 90/50 mm Hg, blood pressure greater than 170/110 mm Hg, heart failure, and coronary disease that produces unstable angina.

Sources and how this letter was sealed

  1. FDA / Pfizer, Viagra (sildenafil citrate) US prescribing information, sections 2, 4, 5, 6.1, 7, 8, 12, 14.
  2. DailyMed VIAGRA sildenafil citrate tablets
  3. Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 1998;338:1397-1404.

Method in brief: open primary sources, annotate against the current FDA label, countersign by Dr. Nora Lindqvist, MD, then seal with a dated review. Full walk-through on the method page and editorial standards.

How to cite this page - Vancouver style

Juvia Pharma Drug Reference. Fifty milligrams about an hour before activity [Internet]. Stockholm: Juvia Pharma; 21 October 2026 [cited 2026 Aug 21]. Available from: https://juviapharma.com/letters/sildenafil/

Desk thread

Answers follow the U.S. Viagra prescribing information.

Stina Qvist, Norrkoping writes

Is 25 mg the real first dose for everyone?

Desk reply

As-needed Viagra for ED starts at 50 mg taken about one hour before sexual activity. Viagra may be taken from 30 minutes to 4 hours before sexual activity. The as-needed dose may be 100 mg based on individual efficacy and tolerability. A 25 mg as-needed tablet may be used when a lower dose is needed. In most patients the maximum dosing frequency is once per day.

Oddvar Holm, Molde writes

I took 50 mg after a steak and it did nothing. Do I go to 100 mg tonight?

Desk reply

A high-fat meal delayed the mean Tmax of sildenafil by 60 minutes. Mean Cmax was reduced 29 percent after that meal. Viagra may be taken with or without food. In the fasted state, maximum plasma concentrations arrive between 30 and 120 minutes. The median Tmax in the fasted state is 60 minutes.

Tore Nilsen, Alesund writes

Can I take a second 50 mg four hours later if the first failed?

Desk reply

As-needed Viagra for ED starts at 50 mg taken about one hour before sexual activity. Viagra may be taken from 30 minutes to 4 hours before sexual activity. The as-needed dose may be 100 mg based on individual efficacy and tolerability. A 25 mg as-needed tablet may be used when a lower dose is needed. In most patients the maximum dosing frequency is once per day.

Liis Saar, Narva writes

My sitting blood pressure runs 178/112. Is 50 mg still the first tablet?

Desk reply

Viagra was not administered to men with myocardial infarction, stroke, or a life-threatening arrhythmia within the last 6 months in clinical trials. Until further information is available, Viagra is not recommended in that group. The same not-recommended list includes resting blood pressure less than 90/50 mm Hg, blood pressure greater than 170/110 mm Hg, heart failure, and coronary disease that produces unstable angina.

Ida Skov, Horsens writes

I keep nitroglycerin for chest pain. How long after 50 mg is a nitrate allowed?

Desk reply

The safe time interval between Viagra and organic nitrate administration is unknown. Plasma levels of sildenafil at 24 hours post dose are about 2 ng/mL compared to approximately 440 ng/mL at peak after 100 mg in healthy volunteers. In the event of an angina attack after Viagra, nitrates should still not be administered. If nitrates are deemed medically necessary in a life-threatening situation, at least 24 hours should have elapsed.

Before you start, stop, or change any medicine mentioned above, run it past your prescriber or pharmacist - they hold your chart, this despatch does not. Desk notice.

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