Checked against the current FDA label, named clinical trials, and the sources listed on this site.
01Narcolepsy dosing
Provigil for narcolepsy starts at 200 mg taken once a day in the morning. The dose may be 400 mg based on individual efficacy and tolerability. A 100 mg tablet may be used when a lower dose is needed. In most patients the dosing frequency is once per day. Provigil may be taken with or without food.
Sources and how this letter was sealed
FDA, Provigil US PI: C-IV; rash / SJS / TEN / DRESS; contraceptive backup; psychiatric reactions.
Method in brief: open primary sources, annotate against the current FDA label,
countersign by Dr. Nora Lindqvist, MD, then seal with a dated review.
Full walk-through on the method page and
editorial standards.
How to cite this page - Vancouver style
Juvia Pharma Drug Reference. Modafinil is Schedule IV [Internet]. Stockholm: Juvia Pharma; 21 October 2026 [cited 2026 Aug 21]. Available from: https://juviapharma.com/postscripts/provigil-schedule-caveat/
Desk thread
Answers follow the U.S. Provigil prescribing information.
Nora-Lis Berg, Umea writes
What dose does narcolepsy start at?
Desk reply
Provigil for narcolepsy starts at 200 mg taken once a day in the morning. The dose may be 400 mg based on individual efficacy and tolerability. A 100 mg tablet may be used when a lower dose is needed. In most patients the dosing frequency is once per day. Provigil may be taken with or without food.
Petri Nieminen, Mikkeli writes
Can the daily dose go to 400 mg?
Desk reply
Provigil for narcolepsy starts at 200 mg taken once a day in the morning. The dose may be 400 mg based on individual efficacy and tolerability. A 100 mg tablet may be used when a lower dose is needed. In most patients the dosing frequency is once per day. Provigil may be taken with or without food.
Ane Kristoffersen, Bergen writes
How often is Provigil taken?
Desk reply
Provigil for narcolepsy starts at 200 mg taken once a day in the morning. The dose may be 400 mg based on individual efficacy and tolerability. A 100 mg tablet may be used when a lower dose is needed. In most patients the dosing frequency is once per day. Provigil may be taken with or without food.
Before you start, stop, or change any medicine mentioned above, run it past your prescriber or pharmacist - they hold your chart, this despatch does not. Desk notice.